Gene Co-Expression Networks Restructured Gene Fusion in Rhabdomyosarcoma Cancers
نویسندگان
چکیده
منابع مشابه
Gene co-expression networks via biclustering Differential gene co-expression networks via Bayesian biclustering models
Identifying latent structure in large data matrices is essential for exploring biological processes. Here, we consider recovering gene co-expression networks from gene expression data, where each network encodes relationships between genes that are locally co-regulated by shared biological mechanisms. To do this, we develop a Bayesian statistical model for biclustering to infer subsets of co-re...
متن کاملGene Reachability Using Page Ranking on Gene Co-expression Networks
We modify the Google Page-Rank algorithm, which is primarily used for ranking web pages, to analyze the gene reachability in complex gene co-expression networks. Our modification is based on the average connections per gene. We propose a new method to compute the metric of average connections per gene, inspired by the PageRank algorithm. We calculate this average as eight for human genome data ...
متن کاملCharacterizing the relationship between protein-fusion and gene co-expression.
A pair of distinct proteins in one organism may most closely match different parts of the same protein in another organism. A comparison of all proteins from the genome of Saccharomyces cerevisiae and all proteins from 24 prokaryotic genomes yields 1010 pairs of yeast proteins whose homologs are parts of one protein from a prokaryotic genome. Marcotte et al. (Science 285:751-3) showed that prot...
متن کاملComparison of Gene Co-expression Networks and Bayesian Networks
Inferring genetic networks is of great importance in unlocking gene behaviour, which in turn provides solutions for drug testing, disease resistance, and many other applications. Dynamic network models provide room for handling noisy or missing prelearned data. This paper discusses how Dynamic Bayesian Networks compare against coexpression networks as discussed by Zhang and Horvath [1]. These s...
متن کاملMycobacterium tuberculosis HspX/EsxS Fusion Protein: Gene Cloning, Protein Expression, and Purification in Escherichia coli
Background: The purpose of this study was to clone, express, and purify a novel multidomain fusion protein of Micobacterium tuberculosis (Mtb) in a prokaryotic system. Methods: An hspX/esxS gene construct was synthesized and ligated into a pGH plasmid, E. coli TOP10 cells were transformed, and the vector was purified. The vector containing the construct and pET-21b (+) plasmid were digested ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genes
سال: 2019
ISSN: 2073-4425
DOI: 10.3390/genes10090665